One madness you have to give up — this material madness — and you have to become mad after Krsna. Then your life is successful. That madness is exhibited by Caitanya Mahaprabhu:

yugayitam nimesena
caksusa pravrsayitam
sunyayitam jagat sarvam
govinda-virahena me

That madness is wanted. Yugayitam nimesena: one moment appears to be one yuga. One yuga means twelve years. So yugayitam nimesena caksusa pravrsayitam. Crying. There is tears in the eyes like the torrents of rain. Yugayitam nimesena caksusa… Sunyayitam jagat sarvam: “I feel the whole world is vacant.” Why? Govinda-virahena me. This madness is wanted, without Govinda; that madness. So that madness fully exhibited in Vrndavana by the gopis. They were mad after Krsna. When Krsna left Vrndavana, went to Mathura, they became so mad that they had no other business than caksusa pravrsayitam, simply crying torrents of rain. That is wanted. That is Vrndavana life.

From Srila Prabhupada’s lecture on Srimad-Bhagavatam 1.7.11 — September 10, 1976, Vrndavana